The most annoying video game sounds

[Weegee]

PRANKSTER COMET DETECTED

HONK HONK

HONK

[ShadowBrain]

Oh Christ, yes. That's about a third of the reason I have no incentive to get every "extra" star in SMG2.

[Ninjap00]

As for the Pokemon thing, supposedly the "DANGER" warning alarm will be replace by faster-paced music in Black and White.  That's one thing they've definitely improved.

It is, and actually it sounds really cool. The alarm is part of the music, and it's not loud and obnoxious like it used to be.
http://www.youtube.com/watch?v=RHItAqaW_EA

[SushieBoy]

All the dialogue in the 3D Sonic games, especially that in Shadow the Hedgehog.

FIND THE COMPUTER ROOM

[PaperLuigi]

My heart jumps a bit whenever I get hit by a crit in Team Fortress 2. The noise it makes is not technically annoying but it's still unpleasant.

[Electric]

HELLO! WATCH OUT!