Yes, stick rotating in Mario Party and other such games were awful for me, made my palms really red. Another thing that kills my thumb are soft D-pads. I don't really know why, but they cause more pain than clicky ones. I also distinctly remember getting a really really sore right thumb from pressing the C buttons in Tony Hawk on the N64, because I would often hold a trick, then slide my thumb over into another trick, causing them to get scratched and pretty raw. It hurt.