-A new F-ZERO. It's about time, really, and now that I think of it I'm rather glad there wasn't a Wii edition. Trying to imagine the disasters it'd cause trying to dumb down the controls to work with the Wii wheel make me weep.
Plus a 3-D F-ZERO IN 3-D would probably be really impressive.
-Elite Beat Agents 2.
-Apollo Justice needs another game. Edgeworth is getting his second already and Apollo hasn't even been talked about. Wat.
-Always up for a Pokémon Mystery Dungeon that doesn't have the pitiful models from My Pokémon Ranch. Though I wonder what they will do with it if they make another one--use only gen 5 'mons until you finish the game? Add gen 5 monaters and kick out some of Sky's starters? Completely redo the personality thing at the beginning and add more results?
-Something Kirby-related, and once again, something his games have never seen before.
-A new Viewtiful Joe. It's begging to happen here, man, just think about it.
-Not Mario & Luigi. One of the greatest things about the series' charm is its superbly animated sprites. 2-D, one-frame-at-a-time, raw animation. I say M&L and Paper Mario should actually trade their seats on console/handheld this time and M&L4 needs to sport high-res, 100% 2-D graphics as a Wii (or whatever) game.
This wish-list became longer than I expected.