I nominate the upcoming version of Resident Evil 4. The orginial already had a pretty weird one (at first), but the Wii version sounds crazy. Basically, you swing the controller to knife nearby enemies; you just swing it, that's all. You hold down B (the trigger button, usually used for shooting) to draw your gun, and A to shoot. The article I read said nothing about reloading or how the D-Pad will be used. For the events that usually require mashng A (or X on the PS2), you must instead wiggle the controller left and right, which sounds tiring. Of course, it may end up being very easy-to-use, but on paper, at least, it sounds bizarre.