What If?...

[Glorb]

Then they would go forward in time and use Crash Bandicoot and replace Crash with Mario.

What if Nintendo killed off Mario and replaced him with Peach?

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"We get signal. Somebody set up us the bomb!" "What you say!" "All your base are belong to us!"
-Last Alert (PS1)

[PaperLuigi]

The whole series would blow monkey chunks.

What if Mario had traveled to the real world to drink a glass of milk?

"You fools! You''ve messed with the natural ordaaaaaaa!!!"~ The story telling crow from the Grim Adventures of Billy and Mandy.

[The Blue Toad]

Then someone would say:  "Hey!  Some little italian dude is drinkin' my milk!....That MY milk!...He got NO right drinkin' it!"

What if Ghonolorc was a word?

“A wagon full of pamcakes?  In the Champeen ship?!  I’d like to see ya try!” ~ Homestar Runner        

[Suffix]

Callard would abandon his business partner for a Bowser that was scarier.

What if landscapes were like the optical side of a CD?

[Glorb]

That everything would be all trippy and we'd have seizures after the sunrise.

What if Spider-Man kept on his Venom suit for too long, then it escaped and fused with Thor and then Mario? (Semi-actual story from original What If? comics)

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"We get signal. Somebody set up us the bomb!" "What you say!" "All your base are belong to us!"
-Last Alert (PS1)