What [ticks] me off is that no anime, with only a few exceptions (Cowboy Bebop, FLCL, Fullmetal Alchemist) is capable of actually interesting me. First off is the fanbase factor; pretty much the only reason so many people watch anime is because it's from Japan, which annoys me. Another is that they so so often have the same plots and, more annoyingly, sight gags.
But worst of all is that I'm afraid that if I mention watching anime to an anime nerd, they go into a six-hour tirade about Death Note or some nonsense. I'm speaking from experience here.