Of course not! It's just a comic (and a really sweet comic at that...I'd kill for the hardback compilation!)... I mean, you can fit it in the storyline/timeline/whatever if you want, but sheesh... are we gonna start trying to classify game ads as canon, too?
"Oh, you know that one for Yoshi's Island on the Game Boy Advance where he throws an egg at that car? Yeah, do you think that was before or after Super Mario World? He was pretty tall, so maybe he ate a mushroom after Mario beat Bowser..."