He used vegetables in SMB2, bombs and diamonds in Wario's Woods, a bazooka in SMRPG, bananas/koopa shells/lightning/etc in the MK games, a hammer (MP4), punches/kicks/hammers/etc (MPs 5-8, DS), has had a dance off (DDR with Mario), and even deflected projectiles with his bare hands (SSBMelee and Brawl).
In the upcoming New SMB Wii, he can also use Super Mushrooms, Fire Flowers and the like (even ride Yoshi).
Now, I think the answer is yes. :)