I think in the next game, it will start out by Mario and Luigi sitting around a campfire, then Mario and Luigi are joking around by pulling down their pants and farting at the fire.
But the, Mario, being the big windbag that he is, does an IN-fart, sucking in the whole campfire along with Luigi himself. What an ill-fate for LUIGI to be sucked up this time! (I.e. Luigi's Mansion)
So I bet after Mario Sunshine, the next game will be based on Luigi this time and his mission will be to eat all of Mario's poop and bile to find his way out of his insides.
The last boss will be a big giant poop molded into the shape of Bowser and it will throw corn at you.
Then when you beat the game, Mario will happily poop you out along with a lot of dihhereah, then you will see Luigi's big brown smile sticking out of the toilet at the end! Horray!