Here are my predictions:
Nintendo will release the Wii U. People will complain about its launch line-up because it doesn't include Zelda, Metroid, F-ZERO, Star Fox, SSB4, and Half-Life 3. "Hardcore" and "mature" "gamers" will constantly insult the system, Nintendo, and the people who play their games; when confronted with logical arguments about why they're wrong about whatever they're saying, they'll say "none of that matters," "you're wrong anyway," and "Nintendo games are for kids." They'll continue to do this years after the system's launch, no matter what games are released for it and regardless of what happens with Sony and Microsoft in the meantime.
Capcom will release a Monster Hunter game for Wii U and then decide not to bring it to the US. This will **** off Monster Hunter fans, as usual. No one else will care.
Capcom will also port Street Fighter x Tekken to the Wii U. They will bring this to the US, but it will contain copious amounts of paid content, none of which is new. Players will complain because the content in question was free in the versions on other platforms, but these people will be few, as everyone else will already be sick of SFxT by the time the Wii U port is released.
A Harvest Moon game will be released early in the system's lifespan to no fanfare whatsoever. It will be popular in Japan and sell about as well as any other Harvest Moon game does in the US.
Sega will announce a Wii U iteration of Project Diva and a special Hatsune Miku-themed Wii U bundle in Japan. Preorders will sell out half an hour after the announcement. The game will never come to the US.
Sega will also release yet another Super Monkey Ball game, while Namco Bandai releases yet another Katamari Damacy sequel. These will come out early in the system's life and will be ignored by most players.
Arc System Works will port BlazBlue: Continuum Shift Extend to the Wii U, now the game's sixth release platform. It will contain no new content. I'll end up buying it before I get my Wii U anyway, just like with the Vita release of the game.
Pikmin 3 will be pretty cool.