In this sequel to Super Mario World 2: Yoshi's Island, the Yoshis must once again save Baby Luigi. This time, Baby Peach, Baby DK, Baby Wario, and Baby Bowser team up with Baby Mario and the Yoshis during their trek through five worlds.

Yoshi relies on each baby's special ability to progress through the stages. When Baby Mario is on board, you can hit "M" blocks, run fast, and your eggs bounce like they did in the first Yoshi's Island. Baby Peach's parasol lets you ride wind gusts to hard-to-reach areas. Though his weight limits Yoshi's jumping ability, Baby DK's strength lets you climb vines, swing on ropes, and throw exploding eggs. Baby Wario's magnet attracts coins and moves metallic objects. The last baby you'll find, Baby Bowser, shoots fireballs that melt ice and make quick work of enemies.